Modern Molecular Approaches to Drug Design and Discovery

Modern approaches to drug discovery and design: setting the scene.

The raison d'ítre for the drug discovery and development process is to provide safe and effective treatments for diseases. Bringing a new drug to market, however, is a time-consuming and expensive process and it remains an imperative for drug companies that they identify ways in which they can accelerate the identification of potential targets and their screening and development in order to mai...

Computational Approaches for Drug Design and Discovery: An Overview

The process of drug discovery is very complex and requires an interdisciplinary effort to design effective and commercially feasible drugs. The objective of drug design is to find a chemical compound that can fit to a specific cavity on a protein target both geometrically and chemically. After passing the animal tests and human clinical trials, this compound becomes a drug available to patients...

Artificial intelligence approaches for rational drug design and discovery.

Pattern recognition, machine learning and artificial intelligence approaches play an increasingly important role in rational drug design, screening and identification of candidate molecules and studies on quantitative structure-activity relationships (QSAR). In this review, we present an overview of basic concepts and methodology in the fields of machine learning and artificial intelligence (AI...

Modern molecular genetic approaches to psychiatric disease.

Major advances in molecular genetics over the last 15 years have made it possible to identify the genes responsible for human diseases using purely genetic approaches that do not require knowledge about disease pathophysiology. Many successes have been achieved for single gene disorders and methods are being adapted and refined for complex diseases. The main strategies include linkage and assoc...

Modern Approaches to Control Systems Design